| 抑肽酶对心内直视手术围术期组织因子途径抑制物的影响 |
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| 引用本文： | 陈胜喜,李国虎,许廖梅,何争鸣.抑肽酶对心内直视手术围术期组织因子途径抑制物的影响[J].中南大学学报(医学版),1999,24(1):26-28. |
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| 作者姓名： | 陈胜喜 李国虎 许廖梅 何争鸣 |
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| 作者单位： | 湖南医科大学附属湘雅医院胸心外科,长沙,410008 |
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| 摘 要： | 检测２０例体外循环心内直视手术病人围术期血浆组织因子途径抑制物（ＴＦＰＩ）及激活凝血时间（ＡＣＴ），结果发现肝素化后及体外循环过程中ＴＦＰＩ与ＡＣＴ明显升高，二者变化相似，预充液中加入抑肽酶对ＴＦＰＩ的变化无明显影响。提示ＴＦＰＩ在体外循环过程中起抗凝血作用
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| 关 键 词： | 体外循环 组织因子途径抑制物 肝素 激活凝血时间 心脏外科学 |
Affection of aprotinin on tissue factor pathway inhibitor in peri-operation of cardiac direct vision operation |
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| Chen Shengxi,Li Guohu,Xu Liaomei,He Zhengmin.Affection of aprotinin on tissue factor pathway inhibitor in peri-operation of cardiac direct vision operation[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),1999,24(1):26-28. |
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| Authors: | Chen Shengxi Li Guohu Xu Liaomei He Zhengmin |
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| Abstract: | Twenty patients underwent cardiac operation with cardiopulmonary bypass(CPB). We collected their blood samples during peri operation and measured tissue factor pathway inhibitor(TFPI) and active coagulation time(ACT). The results were that TFPI and ACT were significantly increased after heparin injection and during CPB. The changes of TFPI and ACT were similar and pathophysiological; it was evident that heparin stimulated TFPI release and ACT prolonged during cardiac operation with CPB. Aprotinin did not affect the change of TFPI. The results suggest that TFPI has the effect on anticoagulation during CPB. |
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| Keywords: | cardiopulmonary bypass tissue factor pathway inhibitor * aprotinin heparin active coagulation time * heart surgery |
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