肾衰宁联合金水宝对慢性肾功能衰竭肾小管损害保护作用的临床观察

目的寻找提高治疗慢性肾功能衰竭(肾衰)肾小管损害临床疗效的最佳中西医结合治疗方法,并探讨其作用机制。方法70例慢性肾衰患者按随机原则分为两组。治疗组36例,在低蛋白饮食、纠正水和电解质及酸碱平衡失调、控制高血压及抗感染等一般治疗基础上,加用中药肾衰宁(由丹参、红花、太子参、甘草、大黄、牛膝等组成)及金水宝治疗;对照组34例,加服包醛氧化淀粉。两组均治疗3个月。观察治疗前后尿-N-乙酰-β-D氨基葡萄糖苷酶(NAG)、β2微球蛋白(β2MG)、24 h尿蛋白定量(24 h UTP)、血肌酐(SCr)、尿素氮(BUN)变化。结果与治疗前比较,对照组治疗后除BUN差异有显著性外(P<0.05),NAG、β2-MG、24 h UTP和SCr差异均无显著性;治疗组治疗后NAG、β2MG2、4 h U TP、SCr、BUN均显著降低,差异有显著性(P<0.05或P<0.01);与对照组治疗后比较,治疗组差异均有显著性(P<0.05或P<0.01)。治疗组有2例患者出现腹泻,经减少用药量后症状缓解。结论肾衰宁联合金水宝对慢性肾衰肾小管损害具有明显的保护作用。

Clinical Observation of Protective Effect on Renal Tubular Injury by Shenshuaining Combined with Jinshuibao in Chronic Renal Faillure

Objective To search the optimization therapy of renal tubular injury of Chronic Renal Failure(CRF) with combined TCM and western medicine,moreover,toapproach the therapy mecharism.Methods 70 cases of such patients were divided into two groups randomly.The treatment group(36 cases) were take chinese crude drug of Shenshuaining(Salvia miltiorrhiza,Safflower,Radix pseudostell,Glycyrrhiza,Rhubarb,achyranthes root,ect.) and capsule of Jinshuibao base on the general treatment of Low-protein diet and correcting th...