肝组织应变参数无创性诊断肝纤维化的可行性研究

目的介绍一种由肝组织二维灰阶超声视频分析获得的应变参数,并评价其诊断慢性乙型肝炎肝纤维化的可行性。方法 27例慢性乙型肝炎患者(慢性肝病组)及8例肝右叶囊肿患者(对照组)纳入本研究,采集每位患者平静呼吸时剑突下肝组织纵切面上的二维灰阶超声视频,分析视频获得肝组织的最大累积呼吸应变值(MARS)。以肝组织活检诊断的肝纤维化病理分期作为诊断标准,应用受试者特征曲线(ROC)评价MARS诊断慢性乙型肝炎肝损害的价值。结果对照组与慢性肝病组的MARS值分别为(29.44±10.44)%及(16.70±6.60)%。经独立样本t检验,前者明显高于后者(P=0.008)。以MARS诊断肝纤维化S≥S1及S=S4,ROC曲线下面积分别为0.889及0.741。结论基于灰阶超声视频分析的MARS可以无创性诊断肝纤维化,是一种新颖、经济及可行的方法。

Feasibility of liver strain parameter on diagnosis of hepatic fibrosis

Objective A novel parameter from B-mode videos of conventional ultrasound system was introduced in this study.The diagnostic feasibility of this parameter for evaluation of hepatic fibrosis was to investigate.Methods Twenty-seven patients with chronic hepatitis B and eight patients with hepatic cysts in right lobe as control were enrolled.B-mode ultrasonography videos of hepatic movement under the ensisternum in the sagittal plane were captured during silent breath.The maximal accumulative respiration strai...