Hemophagocytic syndrome associated with retinoic acid syndrome in acute promyelocytic leukemia |
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Authors: | García-Suárez J Bañas H Krsnik I De Miguel D Reyes E Burgaleta C |
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Affiliation: | Service of Hematology, Príncipe de Asturias University Hospital, Alcalá de Henares, Madrid, Spain. jgarciasu.hupa@salud.madrid.org |
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Abstract: | A 56-year-old woman with an acute promyelocytic leukemia (APL) developed a severe all-trans-retinoic (ATRA) syndrome on day 17 of treatment. Shortly after, she presented a picture of pancytopenia, hepatosplenomegaly, increased triglycerides, ferritin, and liver enzymes. A bone marrow biopsy showed abundant macrophages and no evidence of leukemia. Tests for secondary hemophagocytic syndrome (HPS) were negative. A diagnosis of HPS was made. Treatment with dexamethasone and high-dose immunoglobulins was unsuccessful. Consolidation chemotherapy with idarubicin and ATRA rapidly reversed the HPS. The HPS in this patient could be related to the release of macrophage-stimulating cytokines by APL cells during ATRA syndrome. |
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Keywords: | acute promyelocytic leukemia hemophagocytic syndrome ATRA syndrome |
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