复发性外阴阴道念珠菌病患者阴道局部免疫状态的变化

目的：探讨阴道局部免疫状态与复发性外阴阴道念珠菌病（RVVC）发病的关系。方法：用ELISA法测定外阴阴道念珠菌病（VVC）和RVVC的妇女阴道灌洗液中IgE的浓度及IFN-γ、IL-4的表达水平，以健康体检妇女为对照组。结果：①IgE浓度测定：RVVC组IgE浓度明显高于VVC组和对照组（P〈0．05），VVC组高于对照组（P〈0．05）。②细胞因子测定：VVC和复发VVC的妇女阴道灌洗液中IL-4和IFN-γ的表达水平均显著高于健康对照组，RVVC组较VVC组的IL-4的表达水平有显著性差异（P〈0．05）；而IFN-γ的表达水平无显著性差异（P〉0．05）。结论：阴道局部免疫状态异常可能与念珠菌性阴道炎发病和复发有关。

The change of local immune condition of vagina in recurrent vulvovaginal candidiasis patients

Objective：To investigate the relationship between the local immune condition of vagina and the pathogenesis of recurrent vulvovaginal candidiasis.Mcthods：Objectives were divided into 2 gronps：vulvovaginal candidiasis group （VVC） and recurrent vulvovaginal candidiasis group（RVVC）.The lavage of the vagina,concentration of IgE and expression level of the IL-4 and IFN-γ were all measured by ELISA, and compared with normal controls.Results ①Concentration of IgE： the IgE concentration of RVVC group was higher than that of VVC and normal control group. There was significant difference among three groups （P〈0.05）.②Level of Cytokine：The level of IL-4 and IFN-γ in VVC and RVVC group was significantly and respectively higher than that in normal controls （both P〈0.05）; the level of IL-4 in RVVC group was higher than that in VVC group,while no significant difference in the level of IFN-γ between RVVC and VVC group was found （P〉0.05）.Conclusion： The abnormality of local immune condition of vagina might participate in the pathogenesis and the recrudescence of vulvovaginal candidiasis.