小剂量CHG预激方案治疗老年人急性髓系白血病的临床研究 |
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引用本文: | 刘加强,冷静,桑磊,李同英. 小剂量CHG预激方案治疗老年人急性髓系白血病的临床研究[J]. 白血病.淋巴瘤, 2009, 19(10): 347-348,351. DOI: 10.3760/cma.j.issn.1009-9921.2010.06.009 |
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作者姓名: | 刘加强 冷静 桑磊 李同英 |
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作者单位: | 山东省日照市人民医院血液科,276826; |
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摘 要: | Objective To explore the efficacy and side effect of inductive chemotherapy with lowdose,cytarabine,homoharringtonine and granulocyte colony-stimulating factor(CHG) in elderly acute myeloid leukemia(AML). Methods Thirty-five elderly patients (age>60 years) with AML were enrolled for the initial treatment with CHG regimen,The CHG regimen consisted of cytarabine 10 mg/m2 per 12 h by subcutaneous injection,days 1-14,homoharringtonine 1 mg/m2 per day by intravenous continuous infusion,days 1-14,and G-CSF 200 μg/m2 per day by subcutaneous injection 12 h before chemotherapy,days 0-14. G-CSF only was used when white blood cell count(WBC) was less than 20×109/L during the whole course. Results After the first course,12 patients achieved complete response (CR),15 patients achieved partial response(PR),and 8 patients had no response(NR). After the second course,5 of 15 PR patients achieved CR,2 of 8 NR patients achieved PR. The total effective rate was 82 % (29/35). Of those 17 CR patients,eleven patients continued maintenance therapy and remained in remission for 12-34 months with a median CR duration of 18 months,the other 6 patients relapsed and were treated with original regimen,including one achieved CR again,4 achieved PR,and 1 achieved NR. The CHG regimen had mild hematologic toxicities and no severe nonhematologic toxicities. Conclusion CHG regimen is effective and well tolerated in remission for elderly AML.
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关 键 词: | 白血病 老年人 粒细胞集落刺激因子 高三尖杉酯碱 阿糖胞苷 低剂量 |
Inductive chemotherapy with low-dose CHG stimulating regimen in elderly acute myeloid leukemia |
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Abstract: | |
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Keywords: | LeukemiaAgedGranulocyte colony-stimulating factorHomoharringtonineCytarabineLow-dose |
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