健康体检人群乙肝血清标志物流行病学调查分析

目的 通过对我院2009年度14 865名健康体检人员的乙型肝炎病毒血清标志物检测结果进行分析,了解健康体检人群乙肝血清标志物的流行特点,初步探讨体检医师在工作中如何更好地关注和保护乙肝病毒携带者的权益.方法 抽取14 865名健康体检人员全血标本进行血清学标志物流行病学调查,用酶联免疫吸附试验(ELISA)检测乙型肝炎病毒(HBV)血清标志物:HBsAg、抗-HBs、HBeAg、抗-Hbe和抗-HBc.结果 共抽查14 865人,男女性别比1.47:1,20～40岁者占82.41%,HBsAg阳性率为14.43%,男性阳性率16.46%.女性阳性率11.45%,男女差异有显著意义(x2=14.59,P=0)).其中抗-HBs阳性率64.58%,五项血清学指标全阴性占19.61%.结论 乙肝病毒血清学标志物检测的健康体检人群年龄相对集中,以20～40岁为主,HBsAg阳性率要高于2006年广东省调查水平,且HBsAg阳性率男性高于女性,仍有19.61%的患者需接种乙肝疫苗,体检医师应在加强乙肝防治、保护乙肝病毒携带者权益的工作中起更为积极的作用.

A Study on the Prevalent Characteristic of Hepatitis B Virus Markers in Healthy physical Check-up

Objective To know the prevalent characteristic of hepatitis B vims markers in healthy physical check-up in Guangzhou region, primary discuss the doctor how to concern and protect hepatitis B virus carriers' right. Methods 14865 physical check-up patients in our physical examination center in 2009 were sampled. HBsAg , anti-HBs , HBeAg ,anti-HBe and anti-HBc in blood samples were examined by using ELISA method. Results 14865 cases were sampled .The sex ratio of 14865 cases was 1.47:1. The positive rate of HBsAg was 14.43% .The positive rates of male and female were 16.46% and 11.045% respectively. There were significant difference between the two groups(x2= 14.59, P=0)).Anti- HBs positive rate was 64.58% ,but all HBVM negative rate was 19.61% .Conclusion HBV infection rate was higher than the results investigated in 2006 of Guangdong Province. The positive rate of male was higher than female. There were still 19.61% patients need to be inoculated with hepatitis B vaccine. The doctor should play more effective role in strengthening the prevention and control of Type B hepatitis and protecting the legal right of hepatitis B virus carriers.