血透患者丙型肝炎病毒感染情况调查

目的　了解血液透析(血透)患者丙型肝炎病毒(HCV)感染情况,进一步做好上述人群医院感染控制工作。方法　对1999～2 0 0 3年间的76例血透患者,采用酶联免疫吸附试验(ELISA)法于血透前后检测抗HCV ,对阳性率进行对比分析。结果　血透前抗HCV检测阳性率为9.2 1% ;6 9例血透前抗HCV阴性患者血透后抗HCV阳性率为15 .94 %。血透年限<2年者抗HCV阳性率为9.38% ,明显低于>2年者抗HCV阳性率2 1.6 2 % ,两者相比,差异有高度显著性(P <0 .0 1) ;不同年龄和性别抗HCV阳性率差异无显著性(P >0 .0 5 )。结论　血透患者是HCV感染和传播的高危人群,且感染率随血透年限的延长而增高;医院应做好消毒隔离工作,防止医院内交叉感染的发生。

Investigation on the infection with hepatitis C virus in hemodialysis patients

Objective To investigate hepatitis C virus (HCV) infection in hemodialysis patients and to improve the control of nosocomial infection of HCV. Methods Anti-HCV of 76 hemodialysis patients before and after hemodialysis in a hospital from 1999 to 2003 was detected with ELISA method, the positive rates of anti-HCV were compared and analyzed. Results The positive rate of anti-HCV in patients was 9.21% and 15.94% before and after hemodialysis respectively. The anti-HCV positive rate in patients received less than 2 years hemodialysis treatment was 9.38% , which was much lower than that ( 21.62% ) in patients received more than 2 years hemodialysis (P< 0.01 ). There was no distinct difference in anti-HCV positive rate between different age and gender. Conclusion Hemodialysis patients are high risk population for infection with HCV. HCV infection rate increases with the prolongation of hemodialysis. In order to control the HCV infection in hemodialysis patients, it is important to reinforce the disinfection and sterilization practice.