| Abstract: | The antimutagenic effect of Cortex acanthopanasia Radicis(CAR) has been studied by mean of micronucleus test of mouse bone marrow polychromatic erythrocyte (PCE) and mouse spermatid malformation test. The results indicated that chinese medicine CAR itself has no genotoxic effect. The inhibition rates of CAR(1g/kg,2g/kg,4g/kg) to micronuclei was respectively 73.27%,50.5% and 63.37% (P<0.01),and inhibition rates of CAR to spermatid malformation was 84% (1g/kg), 81.45%(2g/kg) and 73.45% (4g/kg) (P<0.01). It is suggested that CAR can significantly inhibit the genetic damage of germ cells and stomatic cells induced by MMC. |
