| 肺心病患者血维生素E测定及其与GSH－Px／LPO和TXA_2／PGI_2平衡 |
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| 引用本文： | 陈真如,尹静萍.肺心病患者血维生素E测定及其与GSH－Px／LPO和TXA_2／PGI_2平衡[J].现代医学,1996(2). |
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| 作者姓名： | 陈真如 尹静萍 |
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| 作者单位： | 南京铁道医学院附院呼吸科 |
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| 摘 要： | 分别测定２０名健康人、２９例慢性肺心病患者的急性期和缓解或血清维生素Ｅ（ＶＥ）、血浆ＬＰＯ、ＴＸＡ２、ＰＧ－Ｉ２、ＧＳＨ－Ｐｘ值，进行对比，结果急性或血ＶＥ含量减低，缓解期上升．ＧＳＨ－Ｐｘ、ＧＳＨ－Ｐｘ／ＬＰＯ比值与ＶＥ呈正相关，ＬＰＯ和ＴＸＢ２／６－Ｋ－ＰＧＦ１ａ比值与ＶＥ均呈负相关．提示心病急性期机体抗氧化潜力下降，并有ＴＸＡ２／ＰＧＩ２失衡，维持血ＶＥ正常水平有利于提高机体抗氧化能力和维持ＴＸＡ２／ＰＧＩ２平衡．
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| 关 键 词： | 慢性肺心病，脂质过氧化物，谷胱甘肽过氧化物酶，血栓素A_2，前列环素类，维生素E |
A Study of the Value of Vitamin E and its balance Correlation with GSH-Px/LPO and TXA_2/PGl_2 in Patients with Chronic Cor Pulmonale |
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| Chen Zhen-ru,Yin Jing-ping..A Study of the Value of Vitamin E and its balance Correlation with GSH-Px/LPO and TXA_2/PGl_2 in Patients with Chronic Cor Pulmonale[J].Modern Medical JOurnal,1996(2). |
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| Authors: | Chen Zhen-ru Yin Jing-ping |
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| Abstract: | Serum vitamin E, glutathione peroxidase (GSH-Px) of the whole blood,plasma lipid peroxide (LPO), thromboxane A2 (TXA2)and prostaglandin I2 (PGI2) were measured separately in 29 patients with chronic cor pulmonale during exacerbation and relaxation.The results showed that VE decreased during exacerbation and returnted to normal level during relaxation. VE was positively correlated with GSH-Px, GSH/LPO, and negatively correlatively with LPO, TXB2/6-K-PGF1a.These results suggested that there are decreased ability of antioxidation and TXA2/PGI2 imbalance during the exacerbation in corpulmonale; maintaining the normal level of VE may be helpful to restore the ability of antioxidation and keep TXA2/PGI2 balance. |
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| Keywords: | chronic cor pulmonale lipid peroxiade glulathione perxidase thromboxane A2 prostaglandin vitamin E |
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