| microRNA调控胰腺癌干细胞的作用研究进展 |
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| 引用本文： | 洪乐,肖卫东. microRNA调控胰腺癌干细胞的作用研究进展[J]. 中国普通外科杂志, 2019, 28(9): 1137-1142 |
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| 作者姓名： | 洪乐 肖卫东 |
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| 作者单位： | （南昌大学第一附属医院 普通外科，江西 南昌 330006） |
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| 基金项目： | 国家自然科学基金资助项目（81660401， 81860418）；南昌大学研究生创新专项资金资助项目（CX2018184）。 |
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| 摘 要： | 胰腺癌干细胞在胰腺癌的发生、发展、转移及治疗抗性与复发中起着重要作用,但是其中的调节机制仍不清楚。深入研究特定微小RNA调控胰腺癌干细胞的作用,对于阐明胰腺癌发生发展的关键机制具有重要意义,同时有望为胰腺癌的诊治提供新的靶点。
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| 关 键 词： | 胰腺肿瘤；肿瘤干细胞；微RNAs；生物标记，肿瘤 |
| 收稿时间： | 2019-07-02 |
| 修稿时间： | 2019-08-26 |
Research progress of the role of microRNAs in regulating pancreatic cancer stem cells |
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| HONG Le,XIAO Weidong. Research progress of the role of microRNAs in regulating pancreatic cancer stem cells[J]. Chinese Journal of General Surgery, 2019, 28(9): 1137-1142 |
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| Authors: | HONG Le XIAO Weidong |
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| Affiliation: | (Department of General Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China) |
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| Abstract: | Pancreatic cancer stem cells play an important role in the occurrence, development and metastasis as well as the therapeutic resistance and recurrence of pancreatic cancer, but the regulatory mechanisms involved are still unclear. In-depth study of the role of specific microRNA in the regulation of pancreatic cancer stem cells is of great significance for elucidating the key mechanisms of pathogenesis of pancreatic cancer, and is expected to provide a new target for the diagnosis and treatment of pancreatic cancer. |
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| Keywords: | Pancreatic Neoplasms Neoplastic Stem Cells MicroRNAs Biomarkers, Tumor |
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