大株红景天对胃癌合并冠心病患者围术期的心脏保护作用

目的:探讨大株红景天对胃癌合并冠心病患者围术期的心脏保护作用。方法:选择2017年1月—2018年6月69例连续的拟行胃癌切除术的胃癌合并冠心病患者,随机分为观察组与对照组,观察组34例,术前1 d至术后3 d给予大株红景天注射液10 mL静脉输液;对照组35例,以同样的方式给予安慰剂(0.9%氯化钠注射液)。两组患者均于手术前、术后即刻和术后24 h采静脉血检测肌酸激酶同工酶MB(CK-MB)、肌钙蛋白I(cTnI)、N端前脑钠肽(NT-proBNP)和高敏C反应蛋白(hs-CRP),观察患者术后恢复情况及住院期间主要心脏不良事件的发生情况。结果:两组患者基线资料均无统计学差异(均P0.05)。术后两组cTnI、CK-MB、NT-proBNP和hsCRP水平均呈持续升高,但在观察组升高的幅度低于对照组,其中观察组术后顷刻CK-MB水平明显低于对照组,术后24 h所有指标水平均明显低于对照组(均P0.05)。观察组首次排气和排便时间以及住院时间均明显短于对照组(均P0.05)。两组患者住院期间主要心脏不良事件发生率均无统计学差异(均P0.05)。结论:大株红景天对胃癌合并冠心病患者围术期具有心脏保护作用,可促进患者术后恢复。

Cardioprotective effect of Rhodiola Crenulate in patients with gastric cancer and coronary heart disease during perioperative period

Objective: To investigate the cardioprotective effect of Rhodiola Crenulate in patients with gastric cancer and concomitant coronary heart disease during perioperative period.Methods: Sixty-nine consecutive patients with gastric cancer and concomitant coronary heart disease from January 2017 to June 2018 scheduled to undergo gastrectomy were enrolled. The patients were randomly allocated to study group and control group. Thirty-four cases in study group were given 10 mL Rhodiola Crenulate injection by intravenous infusion from preoperative day 1 to postoperative day 3, and 35 cases in control group were given placebo (0.9% saline) administered in the same fashion. The blood samples of the patients were drawn before operation as well as immediately and 24 h after operation to examine the levels of creatine kinase-MB (CK-MB), troponin I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP) and high sensitivity C-reactive protein (hsCRP). The postoperative recovery and the incidence of main adverse cardiac events during hospitalization were observed. Results: The baseline data showed no significant differences between the two groups of patients (all P>0.05). The levels of cTnI, CK-MB, NT-proBNP and hs-CRP in both groups were continually increased after operation, but the increasing amplitudes of them were milder in study group than those in control group, in which, the level of CK-MB in study group was significantly lower than that in control group immediately after operation, and the levels of all above parameters in study group were significantly lower than those in control group 24 h after operation (all P<0.05). The times to first flatus and defecation as well as the length of hospital stay in study group were shorter than those in control group (all P<0.05). The incidence of each adverse cardiac event showed no significant difference between the two groups (all P<0.05). Conclusion: Rhodiola Crenulate has cardioprotective effect for patients with gastric cancer and concomitant coronary heart disease during perioperative period, and can also promote the postoperative recovery of these patients.