理想小鼠结直肠癌肝转移模型的建立及研究进展

结直肠癌是世界上第三大常见的恶性肿瘤,尽管对结直肠癌的发病机制、病理、预防和治疗方面的认识有了许多进展,但患者仍有较高的病死率,其病死率与肝脏转移密切相关,因此研究结直肠癌肝转移的机制和控制疾病进展是改善这些患者生存期的重要措施。近年来小鼠结直肠癌肝转移模型已广泛应用于转移研究,笔者就目前应用于结直肠癌肝转移的小鼠模型及其特点进行综述并分析它们的优缺点。以期为研究者在选择小鼠结直肠癌肝转移模型时提供参考,并为开发更为理想的小鼠结直肠癌肝转移模型指明方向,并为结直肠癌肝转移机制研究提供线索。

Development of ideal mouse models of colorectal cancer liver metastasis and recent progress

Colorectal cancer (CRC) is the third most common malignant tumor in the world. Despite many advances in understanding the pathogenesis, pathology, prevention and treatment of CRC, there is still a high mortality rate. The mortality rate is closely related to CRC liver metastasis. Therefore, studying the mechanism of liver metastasis and controlling disease progression are important measures to improve the survival time of these patients. In recent years, mouse models of CRC liver metastasis have been widely used in metastasis research. Here, the authors address the current mouse models and their characteristics, and analyze their advantages and disadvantages. It is expected to provide references for investigators in selecting the mouse CRC liver metastasis model, and clues for the study of the mechanism of CRC liver metastasis.