细胞周期调节蛋白1在胰腺癌中的表达及临床意义

目的:探讨细胞周期调节蛋白1(Spy1)在胰腺癌组织中的表达及临床意义。方法:用免疫组化法检测85例胰腺癌手术标本中Spy1蛋白的表达,用统计学方法分析Spy1表达与胰腺癌患者临床病理因素及术后生存的关系,并分析患者生存率的影响因素。结果:85例胰腺癌组织中,Spy1高表达55例(64.7%),低表达30例(35.3%)。Spy1蛋白表达与肿瘤大小、TNM分期和分化程度明显有关(均P0.05)。Spy1高表达患者1、3年无瘤生存率与总生存率均明显低于Spy1低表达患者(均P0.05)。Spy1高表达(P=0.023)及淋巴结转移(P=0.005)为胰腺癌患者术后无瘤生存率的独立危险因素,Spy1高表达(P=0.035)及TNM分期(P=0.037)为胰腺癌患者术后总生存的独立危险因素。结论:Spy1蛋白高表达与胰腺癌患者恶性临床病理因素及预后不良相关,可作为判断胰腺癌患者预后的指标。

Expression of speedy/RINGO cell cycle regulator family member A in pancreatic carcinoma and its clinical significance

Objective: To analyze the expression of speedy/RINGO cell cycle regulator family member A (Spy1) in pancreatic carcinoma and its clinical significance.  Methods: The Spy1 protein expressions in 85 surgical specimens of pancreatic cancer tissue were determined by immunohistochemical staining. The relations of Spy1 protein expression with the clinicopathologic factors and postoperative survival of the pancreatic cancer patients were analyzed, and the factors affecting the survival rates of the patients were also analyzed by statistical methods. Results: Of the 85 specimens of pancreatic tissue, high Spy1 expression was found in 55 cases (64.7%), and low Spy1 expression was seen in 30 cases (35.3%). The expression of Spy1 protein was significantly associated with the tumor size, TNM stage and degree of differentiation (all P<0.05). The 1- and 3-year tumor-free survival rate and overall survival rate in patients with high Spy1 expression were significantly lower than those in patients with low Spy1 expression (all P<0.05). The high Spy1 expression (P=0.023) and lymph node metastasis (P=0.005) were independent risk factors for tumor-free survival rate in pancreatic cancer patients, and the high Spy1 expression (P=0.035) and TNM stage (P=0.037) were independent risk factors for overall survival rate in pancreatic cancer patients. Conclusion: High expression of Spy1 protein is associated with malignant clinicopathologic features and poor prognosis in pancreatic cancer patients. It can be used as a prognostic indicator for pancreatic cancer patients.