成纤维细胞生长因子在烧伤创面内变化的临床观察

目的 探讨临床烧伤创面愈合过程中成纤维细胞生长因子（ＦＧＦ）的变化及其作用。方法采用免疫组织化学方法，对烧伤创面肉芽中心部、肉芽与愈合皮肤的交界部、愈合皮肤和自身正常皮肤，以及Ⅲ度烧伤创面不同部位和Ⅱ度烧伤创面愈合过程中ＦＧＦ表达变化进行了观察。结果 Ⅲ度烧伤创面不同部位ＦＧＦ表达强度不同，以创面的肉芽中心部ＦＧＦ含量最多，肉芽与愈合皮肤的交界部ＦＧＦ含量次之，愈合皮肤ＦＧＦ含量较少；每个创面ＦＧ

CLINICAL OBSERVATION ON CHANGES OF FIBROBLAST GROWTH FACTOR IN BURN WOUNDS

Objective\ To investigate the changes of fibroblast growth factor(FGF) in burn wounds.Methods\ The FGF expression in the center of wound granulation, the edge of wound, the healed part of wound, the normal skin of patients, and the heal course of second degree burn wounds were detected by immunohistochemical methods.Results\ The expression intensity of FGF was different in the different sites of third degree burn wounds. The highest contents of FGF was in the center granulation of burn wounds, the less was in the borderline of wound and healed skin, and the least was in the healed skin. FGF expression mainly concentrated in the middle layer of wound, and almost no FGF expression in normal skin. The most FGF expression was occured at 14 days after injury in second degree of burn wound. Conclusion The changes of FGF in wounds are closely related to the wound healing, and rational use of FGF can promote wound healing.