| 血清分子标记物和易感基因对炎症性肠病鉴别诊断的研究进展 |
| |
| 引用本文： | 曹远,童锦禄,冉志华.血清分子标记物和易感基因对炎症性肠病鉴别诊断的研究进展[J].胃肠病学,2014(5):297-300. |
| |
| 作者姓名： | 曹远 童锦禄 冉志华 |
| |
| 作者单位： | 上海交通大学医学院附属仁济医院消化内科 上海市消化疾病研究所 上海市炎症性肠病研究中心,200001 |
| |
| 摘 要： | 炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC),目前两者的鉴别诊断依赖临床症状、内镜检查、病理活检以及实验室和影像学检查等。近年来,IBD相关的生物标记物检测因无创、操作简单、易被患者接受而发展迅速。此外,随着全基因组关联分析(GWAS)的开展,对CD和UC相关遗传突变位点和易感基因的研究取得了较大进展,为疾病诊断提供了新方向。本文就血清分子标记物和易感基因对IBD鉴别诊断的研究进展作一综述。
|
| 关 键 词： | 结肠炎 溃疡性 Crohn 病 诊断 鉴别 生物学标记 易感基因 |
Advances in Studies on Serum Biomarkers and Susceptibility Genes in Differential Diagnosis of Inflammatory Bowel Disease |
| |
| CAO Yuan,TONG Jinlu,RAN Zhihua.Advances in Studies on Serum Biomarkers and Susceptibility Genes in Differential Diagnosis of Inflammatory Bowel Disease[J].Chinese Journal of Gastroenterology,2014(5):297-300. |
| |
| Authors: | CAO Yuan TONG Jinlu RAN Zhihua |
| |
| Institution: | ( Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease; Shanghai Inflammatory Bowel Disease Research Center, Shanghai (200001)) |
| |
| Abstract: | Inflammatory bowel disease （IBD）includes Crohn’s disease （CD）and ulcerative colitis （UC）.The differential diagnosis between CD and UC mainly depends on clinical symptoms,endoscopy,pathological biopsy,laboratory and imaging examinations.In recent years,studies with a variety of IBD-related biomarkers develop rapidly because of its non-invasiveness,simple and easily acceptable.With the development of genome-wide association study （GWAS）,great progress has been achieved in studies of gene mutations and susceptibility genes related with CD and UC,which provides new approach for diagnosis of the disease.This article reviewed the advances in studies on serum biomarkers and susceptibility genes in differential diagnosis of IBD. |
| |
| Keywords: | Colitis Ulcerative Crohn Disease Diagnosis Differential Biological Markers Susceptibility Genes |
| 本文献已被 CNKI 维普 等数据库收录！ |
