| 胆汁反流性胃炎研究进展 |
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| 引用本文： | 魏颖,丁士刚.胆汁反流性胃炎研究进展[J].胃肠病学,2014(5):305-308. |
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| 作者姓名： | 魏颖 丁士刚 |
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| 作者单位： | 北京大学第三医院消化科,100191 |
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| 摘 要： | 胆汁反流性胃炎(BRG)是由过量十二指肠胃反流(DGR)引起的化学性胃病。病理性DGR系由幽门解剖结构异常或胃窦、幽门十二指肠运动失调所致,反流的胆汁酸可诱导胃黏膜细胞凋亡,高浓度胆汁酸是引起胃黏膜肠化生的重要因素。本文拟对DGR的发生机制、胆汁酸对胃黏膜的损伤作用以及BRG诊断和治疗方面的研究进展作一综述。
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| 关 键 词： | 胆汁反流性胃炎 十二指肠胃反流 胆汁酸类和盐类 诊断 治疗 |
Advances in Study on Bile Reflux Gastritis |
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| WEI Ying,DING Shigang.Advances in Study on Bile Reflux Gastritis[J].Chinese Journal of Gastroenterology,2014(5):305-308. |
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| Authors: | WEI Ying DING Shigang |
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| Institution: | ( Department of Gastroenterology, Peking University Third Hospital, Beijing ( 100191 )) |
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| Abstract: | Bile reflux gastritis （BRG）has been recognized as a chemical gastropathy due to excessive duodenogastric reflux （DGR）.Abnormalities in pyloric anatomic structure,as well as antropyloric and duodenal dysmotility are considered to be implicated in the occurrence of pathologic DGR.Bile acid may induce apoptosis of gastric mucosal cells,and high concentration of bile acid plays a crucial role in the induction of intestinal metaplasia in stomach.In this review article, advances in study on BRG,including the mechanisms of DGR,the pathogenic effect of bile acid on gastric mucosa,and the diagnosis and treatment of BRG were summarized. |
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| Keywords: | Bile Reflux Gastritis Duodenogastric Reflux Bile Acids and Salts Diagnosis Therapy |
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