| 脑源性神经营养因子在肠道高敏感中的研究进展 |
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| 引用本文： | 焦黛妍,孙建华.脑源性神经营养因子在肠道高敏感中的研究进展[J].胃肠病学,2014(2):121-123. |
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| 作者姓名： | 焦黛妍 孙建华 |
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| 作者单位： | [1]南京中医药大学,210023 [2]江苏省中医院针灸康复科,210023 |
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| 基金项目： | 本课题由江苏省中医院项目（Y12028）资助 |
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| 摘 要： | 内脏敏感性增高是肠易激综合征(IBS)重要的病理生理学机制之一。近年研究显示,脑源性神经营养因子(BDNF)过表达与IBS内脏高敏感密切相关。BDNF作为神经营养因子参与了神经元的存活、生长、发育、分化、再生过程。肠道组织中大量表达BDNF及其受体,对肠神经系统(ENS)的形成和功能具有调节作用,提示BDNF可能在肠道高敏感的发生机制中发挥重要作用。本文就BDNF在肠道高敏感中的研究进展作一综述。
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| 关 键 词： | 脑源性神经营养因子 肠易激综合征 高敏感 炎症 |
Advances in Studies on Brain-derived Neurotrophic Factor in Intestinal Hypersensitivity |
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| JIAO Daiyan;SUN Jianhua.Advances in Studies on Brain-derived Neurotrophic Factor in Intestinal Hypersensitivity[J].Chinese Journal of Gastroenterology,2014(2):121-123. |
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| Authors: | JIAO Daiyan;SUN Jianhua |
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| Institution: | JIAO Daiyan;SUN Jianhua(Nanjing University of Chinese Medicine, Nanjing 210023;Department of Acupuncture and Rehabilitation, Jiangsu Province Hospital of TCM, Nanjing) |
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| Abstract: | Visceral hypersensitivity is one of the pathophysiologic mechanisms in irritable bowel syndrome （IBS）.Recent studies have shown that visceral hypersensitivity in IBS was closely related with the high expression of brain-derived neurotrophic factor （BDNF）.As one of the neurotrophic factors,BDNF is involved in the survival,growth,development,differentiation and regeneration of neurons.BDNF and its receptor were highly expressed in intestinal tissues and can regulate the formation and function of enteric nervous system （ENS）,which indicates that BDNF may play an important role in the mechanism of intestinal hypersensitivity.This article reviewed the advances in studies on BDNF in intestinal hypersensitivity. |
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| Keywords: | Brain-Derived Neurotrophic Factor Irritable Bowel Syndrome Hypersensitivity Inflammation |
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