<img src="http://www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"><sub>1</sub>-Adrenoceptor subtype involved in the positive inotropic response to phenylephrine in rat atria期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

₁-Adrenoceptor subtype involved in the positive inotropic response to phenylephrine in rat atria

Authors:	Hideki Noguchi Ryusuke Muraoka Shigeru Kigoshi and Ikunobu Muramatsu

Institution:	^a Second Department of Surgery, Fukui Medical School, Matsuoka, Fukui 910-11, Japan ^b Department of Pharmacology, Fukui Medical School, Matsuoka, Fukui 910-11, Japan

Abstract:	Phenylephrine produced positive inotropic responses in isolated rat right and left atria. The responses were competitively inhibited by ₁-adrenoceptor antagonists (prazosin, WB4101 and HV723) with relatively low affinities (pA₂ values close to 8.0). Chloroethylclonidine had no significant effect on the responses to phenylephrine. These results suggest that the positive inotropic response to phenylephrine in rat atria is mediated through ₁-adrenoceptors which cannot be defined by the _1A, _1B subclassification.

Keywords:	sciencedirect com/scidirimg/entities/204e ₁-Adrenoceptor subtype" target="_blank">gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">₁-Adrenoceptor subtype Positive inotropic response Heart (rat)
本文献已被 ScienceDirect 等数据库收录！