精浆中雌激素浓度与精子生成的关系

目的　探讨精浆中雌激素 (E2 )浓度与精子生成的关系及临床意义。方法　选择不育门诊中 64例男性患者精子密度 <2 0× 10 6 ·ml- 1 为少精症组 ,另选择 5 2例有生育史的健康男性精子密度≥ 2 0× 10 6 ·ml- 1 正常精子密度组 ,同时分析精子活动力和活率。应用磁分离酶联免疫分析法测定精浆中的E2 的浓度。结果　正常精子密度组精浆中E2 浓度 (2 0 .10± 2 .42 pg·ml- 1 )明显高于少精症组 (5 .62± 2 .65 pg·ml- 1 ) (P <0 .0 1) ,精浆中E2 浓度与精子密度 (r=0 .3 9,P <0 .0 1)、活动力 (r=0 .42 ,P <0 .0 1)呈正相关。结论　精浆中的E2 浓度的高低影响精子密度、活动力 ,可作为评价Sertoli细胞功能的指标之一

Relationship between concentration of seminal estrogen and spermatogenesis

Objective To study the relationship between concentration of seminal estrogen and spermatogenesis.Methods There are 64 infertile males(sperm density<20×10 6·ml -1 ) in outpatient and 52 well being males who had childbearing history(sperm density≥20×10 6·ml -1 ) in this research .The sperm motility and vitality were analysed in all of subjects. Estrogen level was determined by magnetic enzyme immunoassay.Results Concentration of estrogen in normal sperm group( 20.10 ±2.42pg·ml -1 ) was significantly higher than that of oligozoospermic group(5.62±2.65pg·ml -1 ). There was positive correlation between concentration of seminal estrogen and sperm density( r=0.39,P <0.01), sperm motility( r=0.42,P <0.01). Conclusion Concentration of seminal estrogen can affect sperm density and motility, meanwhile it can evaluate the function of sertoli cell as a marker.