中期因子和微血管密度在涎腺腺样囊性癌组织中的表达

目的探讨中期因子（MK）、微血管密度（MVD）在涎腺腺样囊性癌（SACC）组织中的表达和意义，以及两者之间表达的相关性。方法 采用免疫组织化学方法（SP法）检测60例SACC组织及26例正常涎腺组织中MK、MVD的表达状况及两者之间的相关性。结果 MK在SACC组织中高表达，阳性表达率为70.0%（42/60），正常组织中未见MK表达，二者间差异有统计学意义（P<0.05）。SACC中MVD计数为38.73±8.96，正常涎腺组织中MVD计数为11.15±3.33，二者间差异有统计学意义（P<0.05）。MK、MVD的表达与年龄、性别、分型无关（P>0.05）；与肿瘤的大小、淋巴结转移、TNM分期有关（P<0.05）。MK和MVD在SACC中的表达具有正相关性（r=0.560，P<0.05）。结论MK蛋白的表达、MVD计数的增加与SACC的发生有关，可能是SACC早期诊断指标之一。

Expression of midkine and microvessel density in salivary adenoid cystic carcinoma

Objective This study aimed to investigate the expression of midkine (MK) and microvessel density (MVD) in patients with salivary adenoid cystic carcinoma (SACC) and its clinical significance, as well as detect the correlation between the expression of MK and MVD in SACC. Methods Immunohistochemistry analysis (SP method) for MK and MVD were performed on 60 cases of SACC and 26 cases of normal salivary gland tissue. The expression of MK and MVD, as well as the correlation between the expression of MK and MVD in SACC were detected. Results In SACC, the MK expression rate was 70.0% (42/60), and MK was not expressed in normal tissue. Statistical significance was found between SACC and normal tissue (P<0.05). The MVD values in SACC and normal salivary gland tissues were 38.73±8.96 and 11.15±3.33, respectively. These values were statistically significant (P<0.05). The expression levels of MK and MVD were unrelated to age, gender, and type in SACC (P>0.05), but correlated with tumor size, lymph node metastasis, and tumor–node–metastasis in SACC (P<0.05). The expression of MK and MVD was positively correlated with SACC (r=0.560, P<0.05). Conclusion SACC is correlated with the expression of MK protein and the increase in MVD, which may be some of the early diagnostic markers in SACC.