| 结核分枝杆菌逃逸免疫杀伤机制的研究进展 |
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| 引用本文： | 王飞雨,章乐. 结核分枝杆菌逃逸免疫杀伤机制的研究进展[J]. 中国人兽共患病杂志, 2015, 31(6): 579-582. DOI: 10.3969/cjz.j.issn.1002-2694.2015.06.018 |
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| 作者姓名： | 王飞雨 章乐 |
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| 作者单位： | 石河子大学医学院病理生理学教研室,石河子大学“新疆地方与民族高发病”教育部重点实验室,石河子 832000 |
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| 基金项目： | 国家自然科学基金，the National Science Foundation of China |
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| 摘 要： | 结核分枝杆菌(Mycobacterium tuberculosis, MTB)是典型的胞内致病菌,感染机体后主要寄居于宿主巨噬细胞内。巨噬细胞作为机体防御系统的第一道防线,可通过介导和调控自身及其他细胞凋亡而实现其免疫调节、免疫杀伤及清除病原菌的作用。MTB感染机体后可通过多种途径使巨噬细胞不能正常凋亡,借以逃避巨噬细胞的免疫监视及清除,继而在体内衍生繁殖。进一步探讨结核分枝杆菌逃逸宿主细胞的免疫杀伤机制,对宿主细胞抗结核免疫及人们更好地防治结核病具有深远影响。
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| 关 键 词： | 结核分枝杆菌 巨噬细胞 逃逸机制 |
| 收稿时间： | 2014-07-30 |
Progress in the mechanism of Mycobacterium tuberculosis evasion from the immune killing |
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| WANG Fei-yu,ZHANG Le. Progress in the mechanism of Mycobacterium tuberculosis evasion from the immune killing[J]. Chinese Journal of Zoonoses, 2015, 31(6): 579-582. DOI: 10.3969/cjz.j.issn.1002-2694.2015.06.018 |
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| Authors: | WANG Fei-yu ZHANG Le |
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| Affiliation: | Department of Pathophysiology, Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Medical School of Shihezi University, Shihezi 832000, China |
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| Abstract: | Mycobacterium tuberculosis (MTB) is an intracellular parasite which resides mainly within macrophages. Macrophages are the first line of body's defense system, which complete their immune regulation, immune destruction and removal of pathogenic role by mediating and regulating themselves and other cellular apoptosis. In order to escape from immune surveillance of macrophage, MTB infection can prevent macrophages from normal apoptosis by a variety of ways and survival in the body of host. The mechanisms of immune evasion by Mycobacterium tuberculosis has a profound influence on the host cells killing MTB. |
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| Keywords: | Mycobacterium tuberculosis macrophage evasion mechanism |
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