Assignment of the gene encoding cytosolic phosphoenolpyruvate carboxykinase (GTP) toMus musculus chromosome 2 |
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| Authors: | Janis Lem R. E. K. Fournier |
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| Affiliation: | (1) Department of Microbiology and the Comprehensive Cancer Center, University of Southern California School of Medicine, 90033 Los Angeles, California |
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| Abstract: | The structural gene Pck-1, encoding cytosolic phosphoenolpyruvate carboxykinase (GTP) (PEPCK; EC 4.1.1.32), has been assigned to mouse chromosome 2. This assignment was made based on genomic Southern transfer of rat-mouse and hamster-mouse hybrid DNAs using a rat kidney cloned cDNA of the PEPCK gene as a probe. Conclusive evidence for the cosegregation of the PEPCK gene with mouse chromosome 2 was obtained using a monochromosomal microcell hybrid that selectively retained a Robertsonian translocation between mouse autosomes 2 and 8 and its back-selected hybrid clone. |
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