舒利迭对老年慢性阻塞性肺疾病患者的临床研究

目的:观察舒利迭(丙酸氟替卡松/沙美特罗)对老年稳定期慢性阻塞性肺疾病(COPD)患者的疗效。方法:120例稳定期Ⅲ-Ⅳ期COPD患者分为两组,两组均按COPD稳定期常规处理,对照组给予茶碱缓释片及氨溴索,观察组给予吸入舒利迭,治疗12周,于治疗前后分别测定肺功能(FEV1/FVC,FEV1,FEV1%)、6分钟步行试验、Zung抑郁量表(SDS)。结果:与治疗后对照组相比,观察组肺功能指标明显升高(P<0.05),6分钟步行实验距离增加明显(P<0.05),Zung抑郁量表得分降低(P<0.05)。结论:舒利迭可减轻稳定期COPD患者的临床症状,改善肺功能,提高体力状态,改善情绪。

Clincal study of inhaled fluticasone propionate for older patients with chronic obstructive pulmonary disease

Objective To observe the effect of flutieasone propionate（FP） in the treatment of stable moderate chronic obstructive pulmonary disease（COPD） in elderly patients.Method Total 120 stable moderate COPD patients in stage Ⅲ~Ⅳ were randomly divided into two groups.Both groups were given conventional therapy.The treatment group was given inhaled seretide on the basis of comventional therapy.Pulmonary ventilation function,6-MWD,SDS scores were compared.Results The difference of FEV1,FEV1/FVC and FEV1% between the two groups were not significant before experiment（P0.05）,but at the end of experiment,the index of above mentioned items in the experiment group were higher than the control group,the difference were significant（P0.05）,at the end of experiment,the 6-MWD distant is longer,the scores of Zung depresss questionnaire were lower（P0.05）.Conclusion Seretide can improve clinical symptom and lung function of the patients with COPD.