儿童皮肤非何杰金淋巴瘤与EB病毒的相关性研究

目的研究EB病毒与儿童皮肤非何杰金淋巴瘤(nonhodgkin’lymphoma,NHL)发病的关系。方法采用原位杂交法对36例儿童皮肤NHL的标本进行EB病毒编码的小分子寡核苷酸(Epstein-Barr viralencoded RNA,EBER)检测。结果36例中EBER阳性7例(19.4%),其中皮下脂膜炎样T细胞淋巴瘤(subcutaneous panniculitis-like T-celllym-phoma,SPTCL)5例;外周T细胞淋巴瘤、Burkitt’s瘤各1例;CD30+间变型大细胞淋巴瘤、T淋巴母细胞性淋巴瘤均未见阳性表达。结论EB病毒感染与皮下脂膜炎样T细胞淋巴瘤可能有关,与T淋巴母细胞性淋巴瘤、CD30+间变型大细胞淋巴瘤关系不明显,其与累及皮肤的Burkitt’淋巴瘤的关系有待进一步证实。

The Relationship Between Cutaneous Non-Hodgkin''''s Lymphoma and Epstein-Barr Virus Infection in Childhood

Objective To study the relationship between cutaneous non-hodgkin's lymphoma and epstein-barr virus infection in childhood .Methods The samples of 36 patients with cutaneous NHL were used to detect the EBV-encoded RNA (EBER) by in situ hybridization (ISH).Results Seven of 36 (19.4%) samples showed positive signals including five of thirteen subcutaneous panniculitis-like T-cell lymphoma (SPTCL);one of four unspecified peripheral T-cell lymphoma;one of two Burkitt's lymphoma;none of lymphoblastic lymphoma and CD30 cutaneous anaplastic large cell lymphoma was positive.Conclusion EBV infection might be related to SPTCL and might not be related to lymphoblastic lymphoma and CD30 cutaneous anaplastic large cell lymphoma, the role of EBV in the pathogenesis of Burkitt's lymphoma needs further investigation .