Sialic Acid-Dependent Recognition of Laminin by Penicillium marneffei Conidia |
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| Authors: | A J Hamilton L Jeavons S Youngchim N Vanittanakom and R J Hay |
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| Institution: | Dunhill Dermatology Unit, St John’s Institute of Dermatology, Guy’s Hospital, London, United Kingdom,1. and Microbiology Department, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand2. |
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| Abstract: | Immunofluorescence microscopy demonstrated that laminin bound to the surface of Penicillium marneffei conidia. Attachment of P. marneffei conidia in an adherence assay was inhibited by soluble laminin and anti-laminin antibody. N-Acetylneuraminic acid abolished adherence, indicating an interaction mediated by a sialic acid-specific lectin. |
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