Vasoconstrictor and the anti-inflammatory effects of 7 corticosteroids |
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Authors: | M B Cruns J P Nater F van Oostveen P G M van Der Valk |
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Institution: | Department of Occupational Dermatology, University Hospital of Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands |
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Abstract: | The vasoconstrictor effect of 7 proprietary corticosteroid creams was compared with their effect on patches of allergic contact dermatitis provoked by patch testing in 20 subjects. A parallel between the blanching effect on the normal skin and the anti-inflammatory effect on the eczematous skin was generally found. A modified patch test method using the Finn chamber technique is described, which (with certain restrictions) offers an opportunity of studying the anti-inflammatory effect of corticosteroids on allergic dermatitis under standard conditions. |
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Keywords: | Allergic contact dermatitis Finn Chamber test corticosteroids blanching effect vasoconstrictor assay |
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