Elevated expression of ETS-1 gene in a metastatic, tumorigenic human prostate epithelial cell line transformed by the v-Ki-ras oncogene |
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Authors: | Chen Z Fisher R Li B Kamata T Kung H Lautenberger J Rhim J |
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Affiliation: | OSAKA CITY UNIV,SCH MED,DEPT SURG 1,ABENO KU,OSAKA 545,JAPAN. OSAKA CITY GEN HOSP,DEPT SURG,MIYAKOJIMA KU,OSAKA 534,JAPAN. |
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Abstract: | We investigated the inhibitory effects of intrasplenic combination therapy with OK-432 and recombinant interleukin-2 (IL-2) on liver metastasis of colorectal carcinoma. Intrasplenic administration group significantly inhibited the development of liver metastasis compared with subcutaneous administration group (p<0.05). Combination therapy significantly inhibited the development of subclinical liver metastasis compared with that in the control group. Combination therapy decreased the percentage of cells expressing CD8a, which may be a part of effective factors of combination therapy, and improved overall survival rate. These findings suggested intrasplenic combination therapy with OK-432 and IL-2 might be effective in inhibiting liver metastasis of colorectal carcinoma. |
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