特应性皮炎患者血中结合珠蛋白含量的检测及临床意义

目的：检测特应性皮炎（AD）患者血中结合珠蛋白（Hp）含量，并分析与病情严重程度之间的相关性。方法：采用醋酸纤维素薄膜电泳后比色的方法检测124例特应性皮炎患者（其中轻度40例、中度44例、重度40例）和134例正常对照者血中Hp水平。结果：与正常对照组相比，患者组血中Hp含量明显增高（P〈0．001），其中病情中度和重度患者组均显著增高（P〈0．05），轻度组增高无统计学意义。Hp含量与AD病情严重程度呈正相关（P〈0．001）。结论：Hp可能通过一种负反馈机制来抑制皮损局部的过度炎症反应，而参与了AD患者体内的免疫调节和抗炎作用。

Serum haptoglobin concentrations in patients with atopic dermatitis and its significance

Objective:To detect the serum haptoglobin concentrations in atopic dermatitis(AD)patients and to analyze the correlation between the haptoglobin level and the severity of AD.Methods:The concentrations of haptoglobin in the serum of 124 patients with AD(forty mild cases,forty-four moderate cases and forty severe cases)and 134 normal controls were measured by cellulose membrane electrophoresis and chromatometry.Results:Compared with normal controls,the serum haptoglobin concentration was significantly increased in the patients with AD(P<0.001).The increase of serum haptoglobin concentration in patients with moderate and severe AD was significantly higher(P<0.05),but the increase did not show a significant difference in the patient with mild AD,when compared with normal control group.Positive correlation was found between haptoglobin concentration and the severity of AD.Conclusion:Haptoglobin might play a role in immunoregulation and anti-inflammation in AD patients through a negative feedback mechanism inhibiting hyper-inflammatory reaction in local lesion.