| 速释硝苯地平微丸的研究 |
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| 引用本文： | 陈庆华,张焱.速释硝苯地平微丸的研究[J].中国药学杂志,1995,30(1):20-23. |
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| 作者姓名： | 陈庆华 张焱 |
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| 作者单位： | 上海医药工业研究院 |
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| 摘 要： | 报道了用硝苯地平（Ｎｆ）和聚乙烯吡咯烷酮（ＰＶＰ）制成固体分散体后滚制成Ｎｆ微丸的新工艺。Ｎｆ微丸与市售片剂的溶出度试验表明：其体外累积溶出百分率经０．５ｈ分别为８０％和≤５％，经Ｂｅａｇｌｅ犬口服两剂型的自身对照试验表明，微丸组犬体内血药达峰时明显加快（Ｔ＿（ｍａｘ）＝１ｈ），生物利用度也有显著提高。
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| 关 键 词： | 硝苯地平 微丸 固体分散体 溶出度 |
| 收稿时间： | 1993-12-14; |
Immedlate released nifedipine pellets |
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| Chen Qinghua, Zhang Yan, Lu Weigen, Xiong Quanmei.Immedlate released nifedipine pellets[J].Chinese Pharmaceutical Journal,1995,30(1):20-23. |
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| Authors: | Chen Qinghua Zhang Yan Lu Weigen Xiong Quanmei |
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| Institution: | Shanghai Institute of Pharmaceutical Industry,Shankhai 200040 |
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| Abstract: | A new technique was used to prepare nifedipine pellets by spheronization of sohddispersion of nifedipine(Nf),PVP and some other ingredients,The dissolution rates of Nf pelletsand market Nf tablets were 80%and≤5%respectively,Shorter Tmax and bigger AUC wereproven obviously by pharmacokinetic experiments in Beagles which took the Nf pellets as com-pared with the group of taking the Nf tablets. |
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| Keywords: | nifedipine dispersion dissolution pellet |
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