Microdistributions of prospective BNCT-compound CuTCPH in tissue sections with a heavy ion microbeam. |
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| Authors: | P Stoliar A J Kreiner M E Debray M E Caraballo A A Valda J Davidson M Davidson J M Kesque H Somacal H DiPaolo A A Burlon M J Ozafrán M E Vázquez D Minsky E M Heber V A Trivillin A E Schwint |
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| Affiliation: | Departamento de Física, Argentine Atomic Energy Commission, CNEA, Av. Gral. Paz 1499, CP 1650, Bienos Aires, Villa Martelli, Argentina. |
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| Abstract: | Microdistributions of the prospective BNCT-compound CuTCPH, a carborane-containing tetraphenylporphyrin with one Cu atom in its molecular structure, have been obtained in tissue sections of different organs of tumor-bearing and normal Syrian hamsters injected with the boron compound by employing a heavy ion microbeam. High resolution X-ray spectroscopy following micro-PIXE (Particle Induced X-ray Emission with micrometer-sized beams) with a focused (16)O ion beam was used. Focusing was performed with a heavy-ion scanning high-precision magnetic quadrupole triplet microprobe. Squamous Cell Carcinomas were induced on the right Cheek Pouch of Syrian Hamsters (HCP), sampled, cryo-sectioned and freeze-dried. Two-dimensional maps of elemental concentration were obtained by scanning the beam over the samples. Very non-uniform Cu concentrations were found in all sections. |
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