| 不同基质及促渗剂对奥氮平贴剂体外透皮吸收的影响 |
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| 引用本文： | 李志荣,陈永顺,杜士明,姜华军. 不同基质及促渗剂对奥氮平贴剂体外透皮吸收的影响[J]. 中国药师, 2013, 16(7): 1017-1020 |
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| 作者姓名： | 李志荣 陈永顺 杜士明 姜华军 |
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| 作者单位： | 湖北医药学院附属太和医院药学部,湖北十堰,442000 |
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| 摘 要： | 目的:研究不同基质及促渗剂对奥氮平贴剂体外透皮促渗作用的影响.方法:采用不同基质及促渗剂制备奥氮平贴剂;采用卧式双室扩散池,以离体大鼠皮肤为模型,通过HPLC法测定药物浓度,拟合奥氮平透皮吸收的累积透过量和透过速率.结果:由Duro-Tak 87-4098型压敏胶制备的贴剂具有较好的稳态渗透速率,5%薄荷脑+10%肉豆蔻酸异丙酯合用对奥氮平促渗效果明显,促渗倍率达5.86倍.结论:奥氮平在以5%薄荷脑+10%肉豆蔻酸异丙酯为促渗剂,Duro-Tak 87-4098型压敏胶为基质时具有较好的透皮吸收.
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| 关 键 词： | 奥氮平 贴剂 透皮吸收 促渗剂 |
| 收稿时间： | 2013-01-23 |
| 修稿时间： | 2013-04-28 |
Effect of Matrixes and Different Penetration Enhancers on Transdermal Permeability of Olanzapine in vitro |
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| Li Zhirong,Chen Yongshun,Du Shiming and Jiang Huajun. Effect of Matrixes and Different Penetration Enhancers on Transdermal Permeability of Olanzapine in vitro[J]. China Pharmacist, 2013, 16(7): 1017-1020 |
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| Authors: | Li Zhirong Chen Yongshun Du Shiming Jiang Huajun |
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| Affiliation: | Department of pharmacy, Taihe Hospital Affiliated with Hubei medical College,Hubei Shiyan 442000;Department of pharmacy, Taihe Hospital Affiliated with Hubei medical College,Hubei Shiyan 442000;Department of pharmacy, Taihe Hospital Affiliated with Hubei medical College,Hubei Shiyan 442000;Department of pharmacy, Taihe Hospital Affiliated with Hubei medical College,Hubei Shiyan 442000 |
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