| 大蒜素聚氰基丙烯酸正丁酯纳米粒的制备工艺研究 |
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| 引用本文： | 徐巍,邓树海,李艳辉.大蒜素聚氰基丙烯酸正丁酯纳米粒的制备工艺研究[J].中国新药杂志,2006,15(6):448-451. |
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| 作者姓名： | 徐巍 邓树海 李艳辉 |
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| 作者单位： | 山东大学药学院药物制剂研究所,济南,250012 |
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| 摘 要： | 目的：研制大蒜素聚氰基丙烯酸正丁酯纳米粒并对处方与制备工艺进行优化筛选。方法：以生物降解型聚氰基丙烯酸正丁酯为载体材料，采用乳化聚合法制备大蒜素聚氰基丙烯酸正丁酯纳米粒；以载药量、包封率、形态和粒径分布为评价指标，通过单因素试验考查、均匀设计法优化制备工艺。结果：按优化处方与制各工艺条件，制得纳米粒球形圆整、分散良好，算术平均粒径为113．4nm，粒径分布范围为11．7—146．8nm，载药量为18．57％，包封率为92．87％。结论：经优化筛选出的工艺是大蒜素聚氰基丙烯酸正丁酯纳米粒的最佳制备工艺。
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| 关 键 词： | 大蒜素 纳米粒 聚氰基丙烯酸正丁酯 均匀设计 |
| 文章编号： | 1003-3734（2006）06-0448-04 |
| 收稿时间： | 2005-11-10 |
| 修稿时间： | 2005年11月10 |
The optimal preparation of DATS nanoparticles |
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| XU Wei,DENG Shu-hai,LI Yan-hui.The optimal preparation of DATS nanoparticles[J].Chinese Journal of New Drugs,2006,15(6):448-451. |
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| Authors: | XU Wei DENG Shu-hai LI Yan-hui |
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| Institution: | College of Pharmacy, Shandong University, Jinan 250012, China |
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| Abstract: | Objective; To optimize the formulation and preparation of dially trisulfide-polybutyl cyanoacrylate-nanoparticles (DATS-PBCA-NP). Methods:DATS-PBCA-NP was prepared using an emulsion polymerization method with biodegradable polybutylcyanoacrylate as a carrier material. The preparation procedure was optimized by single factor test and uniform design test associated with the evaluations of drug loading,encapsulation efficiency, shape and size distribution. Result:The nanoparticles of the dially trisulfide (DATS) were globular in appearance and dispersed well. The nanoparticles featured the mean diameter of 113. 4 nm, the size distribution within 11.7 - 146. 8 nm, the mean drug loading of 18. 57% and the mean encapsulation efficiency of 92. 87% . Conclusion:The optimal preparation procedure of DATS-PBCA-NP was achievable. |
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| Keywords: | dially trisulfide(DATS) nanoparticles polybutylcyanoacrylate uniform design |
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