| 川芎嗪对小白鼠实验性肝损伤的保护作用 |
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| 引用本文： | 张明远,郭忠兴,郭朝晖. 川芎嗪对小白鼠实验性肝损伤的保护作用[J]. 黑龙江医药科学, 2000, 23(3): 3-4 |
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| 作者姓名： | 张明远 郭忠兴 郭朝晖 |
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| 作者单位： | 1. 佳木斯大学基础医学院
2. 佳木斯大学一附院 |
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| 摘 要： | 本实验利用四氯化碳诱发小白鼠急性肝损伤模型，通过测定肝组织及血清SOD，GSH－Px和MDA，观察川芎嗪对肝损伤的保护作用，结果表明，川芎嗪能显著提高肝血清SOD GSH－Px活性，减少MDA生成量（P＜0．01），说明川芎嗪有一定程度抗自由基与抗脂质过氧化作用，对四氯化碳肝损伤有显著的保护作用。
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| 关 键 词： | 四氯化碳 肝损伤 川芎嗪 超氧化物歧化酶 谷胱甘肽过氧化物酶 中药 丙二醛 药理 |
Protective effects of ligustrazini on experimental liver injury in mice |
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| Zhang Mingyuan,et al. Protective effects of ligustrazini on experimental liver injury in mice[J]. Heilongjiang Medicine and Pharmacy, 2000, 23(3): 3-4 |
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| Authors: | Zhang Mingyuan et al |
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| Abstract: | Objective: To observe the protective effects of ligustrazini on liver injury Methods: by use of the model of acute liver damage induced by CCl4, and by determining the superoxide dismutase (SOD),glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) in the serum and liver tissue. ReSults: The results showed that compared with control group, Ligustrazini evidently increased the activities of SOD and GSH-Px and decreased the production of MDA (P<0.01) in the liver tissue and serum. |
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| Keywords: | All these suggest that ligustrazini has the effects of anti-free radical and anti-lipid peroxidetion in certain degree and has the protective effects on the liver from damage induced by CCl_4 |
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