| 酯酰辅酶A:胆固醇酰基转移酶的研究进展 |
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| 引用本文： | 王晓微,高明明. 酯酰辅酶A:胆固醇酰基转移酶的研究进展[J]. 中国动脉硬化杂志, 2018, 26(7): 685-690 |
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| 作者姓名： | 王晓微 高明明 |
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| 作者单位： | 河北医科大学基础医学研究所脂代谢研究室 |
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| 基金项目： | 国家自然科学基金面上项目(31771306)；国家自然科学基金青年科学基金(81700386) |
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| 摘 要： | 胆固醇对细胞的存活至关重要,胆固醇及其代谢产物与动脉粥样硬化、癌症、神经退行性疾病等的发病机制有关。酯酰辅酶A:胆固醇酰基转移酶(ACAT)催化细胞内胆固醇的酯化,在细胞内胆固醇的稳态中发挥重要作用,是多种疾病治疗干预的药物靶点。本文将对ACAT对胆固醇代谢的作用及其与疾病的关系进行综述。
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| 关 键 词： | 胆固醇 酯酰辅酶A:胆固醇酰基转移酶 动脉粥样硬化 神经退行性疾病 |
| 收稿时间： | 2018-04-17 |
| 修稿时间： | 2018-05-23 |
The progress of esterase coenzyme A:cholesterol acyltransferase |
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| WANG Xiaowei and GAO Mingming. The progress of esterase coenzyme A:cholesterol acyltransferase[J]. Chinese Journal of Arteriosclerosis, 2018, 26(7): 685-690 |
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| Authors: | WANG Xiaowei and GAO Mingming |
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| Affiliation: | Lipid Metabolism Laboratory, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, China and Lipid Metabolism Laboratory, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, China |
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| Abstract: | Cholesterol is crucial for the survival of cells, and cholesterol and its metabolites are involved in the pathogenesis of atherosclerosis, cancer, neurodegenerative diseases etc. Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes the esterification of cholesterol in cells, and plays an important role in the intracellular cholesterol homeostasis. ACAT is the therapeutic target of many diseases. This article will review the role of ACAT in cholesterol metabolism and associated diseases. |
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| Keywords: | cholesterol acyl-CoA:cholesterol acyltransferase atherosclerosis neurodegenerative diseases |
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