气体信号分子心血管效应的基础与转化研究应加快推进

一氧化氮(NO)、一氧化碳(CO)、硫化氢(H_2S)、二氧化硫(SO_2)等气体信号分子生物学效应与机制的研究为人们对生命活动和疾病发生规律的认识提供了全新的视角。本期专栏中几个团队分别从内源性SO_2/AAT2体系对心肌肥厚时心肌细胞自噬的抑制作用、内源性CSE/H_2S体系拮抗内皮细胞炎症的新机制、外源性氢氧混合气体增加健康人皮肤血流量等方面介绍了各自近期的相关工作。这些研究对进一步了解气体信号分子的心血管效应与机制提供了新认识,也为心血管疾病的防治提供了新思路,具有重要意义。将来该领域的研究仍需在具有生理病理意义的新气体信号分子的发现、体内不同生理病理状态下气体信号分子的作用与机制、气体信号分子之间及与其他信号分子之间的相互作用与途径、内源性气体信号分子便捷检测技术及其水平变化的临床意义、气体信号分子的控释药物研发和临床应用等方面加速推进。

The basic and translational research on cardiovascular effect induced by gaseous signaling molecules are worth acceleration

The investigation on the biological roles and underlying mechanisms of gaseous signaling molecules such as nitric oxide, hydrogen sulfide and sulfur dioxide provides a new perspective to understand life activities and the occurrence of diseases. In the column of this issue, a few well-established research teams showed their recent work on endogenous AAT2/SO₂ system inhibited myocardial cell autophagy during cardiac hypertrophy, endogenous H₂S/CSE system suppressed inflammation of endothelial cells and increased skin blood flow by exogenous hydrogen and oxygen mixed gas, respectively, which provide both a new understanding of the cardiovascular effects and mechanisms induced by gaseous signaling molecules and new ideas for the prevention and treatment of cardiovascular diseases. Research still needs to be accelerated in the area on exploration of new gaseous transmitters, the function, mechanism, network and determination techniques of gaseous signal molecules in different physiological and pathological states and its clinical significance in vivo.