microRNA调节血管钙化的研究进展

血管钙化与心血管疾病死亡风险的增加有着密切联系,然而在患有冠状动脉疾病(CAD)的患者中血管钙化却非常普遍。血管钙化的发病机制类似于骨发育和软骨形成的过程。血管平滑肌细胞转分化为成骨样细胞、钙磷调节失衡、破骨细胞活性和矿物质吸收能力的降低,在促进血管钙化过程中有着重要的作用。目前发现微小RNA(microRNA)通过引导血管平滑肌细胞进行复杂遗传基因重编码以及与血管钙化相关的其他细胞功能反应参与血管钙化的过程。文章将详细介绍关于microRNA介导血管钙化的重要调节作用。

Research progress of the microRNA regulating vascular calcification

Vascular calcification is associated with an increased risk of death from cardiovascular disease, however vascular calcification is common in patients with coronary artery disease. The pathogenesis of vascular calcification is similar to the process development of bone and chondrogenesis. Vascular smooth muscle cells transdifferentiate into osteoblast-like cells, the imbalance of calcium and phosphorus adjustment, osteoclast activity and the decrease of mineral absorption capacity play an important role in promoting vascular calcification. It is now found that microRNA are involved in the process of vascular calcification by directing vascular smooth muscle cells for complex genetic reprogramming and other cellular functional responses associated with vascular calcification. This article presents in detail the important regulation that has so far involved microRNA-mediated vascular calcification.