| 动脉粥样硬化中巨噬细胞介导胞葬作用的研究进展 |
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| 引用本文： | 廖思聪,于杨,王大新,秦树存.动脉粥样硬化中巨噬细胞介导胞葬作用的研究进展[J].中国动脉硬化杂志,2018,26(2):201-206. |
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| 作者姓名： | 廖思聪 于杨 王大新 秦树存 |
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| 作者单位： | 中南大学湘雅二医院心血管内科;泰山医学院动脉粥样硬化研究所;江苏省苏北人民医院医学实验研究中心; |
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| 基金项目： | 国家自然科学基金重大研究计划培育项目(91539114)；山东省泰山学者岗专项基金项目(ts201511057)；国家重大项目973计划项目(2007CB936104) |
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| 摘 要： | 动脉粥样硬化斑块内累积的大量凋亡和坏死细胞是斑块增大、坏死核心形成及斑块破裂的主要原因。生理状态下,机体通过巨噬细胞等吞噬细胞介导的胞葬作用能及时吞噬和清除凋亡细胞。然而近年来研究表明,斑块内凋亡细胞的清除速度远远低于生理状态,其机制与巨噬细胞介导的胞葬功能障碍密切相关。本文综述了巨噬细胞介导的胞葬作用及其功能缺陷在动脉粥样硬化中的研究进展,期望为动脉粥样硬化性心血管疾病防治提供理论和实验基础。
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| 关 键 词： | 动脉粥样硬化 胞葬作用 巨噬细胞 凋亡 |
| 收稿时间： | 2017/9/22 0:00:00 |
| 修稿时间： | 2017/10/24 0:00:00 |
The research progress on macrophage mediated efferocytosis in atherosclerosis |
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| LIAO Si-Cong,YU Yang,WANG Da-Xin and QIN Shu-Cun.The research progress on macrophage mediated efferocytosis in atherosclerosis[J].Chinese Journal of Arteriosclerosis,2018,26(2):201-206. |
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| Authors: | LIAO Si-Cong YU Yang WANG Da-Xin and QIN Shu-Cun |
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| Institution: | Department of Cardiology, Xiangya Second Hospital of Central South University, Changsha 410011, Hunan, China,Institute of Atherosclerosis, Taishan Medical University, Taian 271000, Shandong, China,Medical Experimental Research Center, Northern Jiangsu People''s Hospital, Yangzhou 225001, Jiangsu, China and Institute of Atherosclerosis, Taishan Medical University, Taian 271000, Shandong, China |
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| Abstract: | The accumulation of a large number of apoptotic and necrotic cells in atherosclerotic plaques is the main cause of plaque enlargement, necrotic core formation and plaque rupture. Apoptotic cells are engulfed and cleared quickly by macrophage and other phagocytes mediated efferocytosis in physiological state. However, recent studies have shown that the clearance rate of apoptotic cells in plaque is far lower than that in physiological state, and its mechanism is closely related to macrophage mediated efferocytosis dysfunction. This review summarizes the research progress of macrophage mediated efferocytosis and its functional defects in atherosclerosis, and hopes to provide theoretical and experimental basis for prevention and treatment of atherosclerotic cardiovascular disease. |
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| Keywords: | Atherosclerosis Efferocytosis Macrophage Apoptosis |
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