动脉粥样硬化血管壁的Warburg效应

动脉粥样硬化(As)是一种以动脉血管壁脂质沉积为病理特征的慢性炎症性疾病。致As因素所诱导的血管壁慢性炎症在该疾病的病理进程中起着重要作用。单核细胞/巨噬细胞的能量代谢重新编程与As的发生发展密切相关。Warburg效应是细胞能量代谢的重要方式,该效应可能参与As的某些病理过程,如血管平滑肌增殖、内皮细胞功能障碍和炎症等。本文就As血管壁的Warburg效应进行综述。

The Warburg effect of vessel wall in atherosclerosis

Atherosclerosis (As) is a kind of chronic inflammatory disease, which characterized by the deposition of lipid in vessel wall. Chronic inflammation of vascular wall induced by As factors plays an important role in the pathophysiological process of the disease. The reprogramming of energy metabolism of monocytes/macrophages is closely related to the occurrence and development of As. Warburg effect is an important way of cell energy metabolism. This effect may be involved in some pathological processes of As, such as vascular smooth muscle proliferation, endothelial cell dysfunction, and inflammation. This article reviews the Warburg effect of the vascular wall in As.