| 动脉粥样硬化血管壁的Warburg效应 |
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| 引用本文： | 田清综述,顾洪丰,唐小卿审校.动脉粥样硬化血管壁的Warburg效应[J].中国动脉硬化杂志,2018,26(5):536-540. |
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| 作者姓名： | 田清综述 顾洪丰 唐小卿审校 |
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| 作者单位： | 南华大学医学院神经科学研究所生理学教研室 |
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| 摘 要： | 动脉粥样硬化(As)是一种以动脉血管壁脂质沉积为病理特征的慢性炎症性疾病。致As因素所诱导的血管壁慢性炎症在该疾病的病理进程中起着重要作用。单核细胞/巨噬细胞的能量代谢重新编程与As的发生发展密切相关。Warburg效应是细胞能量代谢的重要方式,该效应可能参与As的某些病理过程,如血管平滑肌增殖、内皮细胞功能障碍和炎症等。本文就As血管壁的Warburg效应进行综述。
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| 关 键 词： | 动脉粥样硬化 Warburg效应 炎症 |
| 收稿时间： | 2018/1/25 0:00:00 |
| 修稿时间： | 2018/4/2 0:00:00 |
The Warburg effect of vessel wall in atherosclerosis |
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| TIAN Qing,GU Hong-Feng and TANG Xiao-Qing.The Warburg effect of vessel wall in atherosclerosis[J].Chinese Journal of Arteriosclerosis,2018,26(5):536-540. |
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| Authors: | TIAN Qing GU Hong-Feng and TANG Xiao-Qing |
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| Institution: | Institute of Neuroscience & Department of Physiology, Medical College, University of South China, Hengyang, Hunan 421001, China,Institute of Neuroscience & Department of Physiology, Medical College, University of South China, Hengyang, Hunan 421001, China and Institute of Neuroscience & Department of Physiology, Medical College, University of South China, Hengyang, Hunan 421001, China |
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| Abstract: | Atherosclerosis (As) is a kind of chronic inflammatory disease, which characterized by the deposition of lipid in vessel wall. Chronic inflammation of vascular wall induced by As factors plays an important role in the pathophysiological process of the disease. The reprogramming of energy metabolism of monocytes/macrophages is closely related to the occurrence and development of As. Warburg effect is an important way of cell energy metabolism. This effect may be involved in some pathological processes of As, such as vascular smooth muscle proliferation, endothelial cell dysfunction, and inflammation. This article reviews the Warburg effect of the vascular wall in As. |
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| Keywords: | Atherosclerosis Warburg effect Inflammation |
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