| 新生滋养血管在动脉粥样硬化形成中的作用及临床意义 |
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| 引用本文： | 李萌,张军平,朱科,漆仲文,邹升. 新生滋养血管在动脉粥样硬化形成中的作用及临床意义[J]. 中国动脉硬化杂志, 2018, 26(1): 91-98 |
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| 作者姓名： | 李萌 张军平 朱科 漆仲文 邹升 |
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| 作者单位： | 天津中医药大学第一附属医院;天津中医药大学研究生院; |
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| 基金项目： | 国家自然科学基金项目(81473634) |
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| 摘 要： | 动脉粥样硬化(As)病变的主要临床危险性在于斑块的不稳定性、易损性。斑块内新生滋养血管(VV)具有结构缺陷,其脆性大、渗漏性高,容易破裂出血,促进炎症反应,也为血细胞及血液可溶性成分进入斑块提供通道,促进As斑块的形成,并且与斑块内出血、斑块破裂及临床心脑血管事件的发生密切相关。深入研究新生滋养血管的功能及关键信号途径在As中的作用,有望从根本上阻止稳定斑块发展为易损斑块,或者阻止不稳定斑块破裂及其并发症的发生。
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| 关 键 词： | 动脉粥样硬化 滋养血管 血管新生 血管成熟化 |
| 收稿时间： | 2017-07-12 |
| 修稿时间： | 2017-09-13 |
Vasa vasorum in pathological process of atherosclerosis and clinical significance |
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| LI Meng,ZHANG Jun-Ping,ZHU Ke,QI Zhong-Wen and ZOU Sheng. Vasa vasorum in pathological process of atherosclerosis and clinical significance[J]. Chinese Journal of Arteriosclerosis, 2018, 26(1): 91-98 |
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| Authors: | LI Meng ZHANG Jun-Ping ZHU Ke QI Zhong-Wen ZOU Sheng |
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| Affiliation: | Department of Cardiology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medcine, Tianjin 300193,Department of Cardiology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medcine, Tianjin 300193,Graduate School, Tianjin University of Traditional Chinese Medcine, Tianjin 300193, China,Graduate School, Tianjin University of Traditional Chinese Medcine, Tianjin 300193, China and Graduate School, Tianjin University of Traditional Chinese Medcine, Tianjin 300193, China |
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| Abstract: | The main clinical risk of atherosclerotic (As) lesions is the instability and vulnerability of plaques. Vasa vasorum (VV) inside the As plaque has structural defects, such as fragile and high leakage of vascular wall. These structural defects lead to plaque rupture and hemorrhage, which promotes inflammatory response, provides channel for leukocyte and blood soluble components entering the plaque and promotes As plaque formation. VV inside the As plaque is closely related to plaque rupture and hemorrhage, and clinical cardiovascular events. Intensive study of the VV function and its related signaling pathway in As is expected to fundamentally prevent As plaque development. |
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| Keywords: | Atherosclerosis Vasa vasorum Neovascularization Vascular maturation |
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