基质金属蛋白酶-2在急性心肌梗死患者血清中的表达 |
| |
引用本文: | 李艳辉,孟晓萍,曲玲. 基质金属蛋白酶-2在急性心肌梗死患者血清中的表达[J]. 中华急诊医学杂志, 2003, 12(4): 231-233,W001 |
| |
作者姓名: | 李艳辉 孟晓萍 曲玲 |
| |
作者单位: | 1. 130041,长春,吉林大学第二临床医院急救医学科 2. 130041,长春,吉林大学第二临床医院心血管内科 3. 吉林省湾沟林业局职工医院 |
| |
摘 要: | 目的:探讨急性心肌梗死(AMI)患者血清基质金属蛋白酶-2(MMP-2)的表达与不稳定斑块的内在联系。方法:应用酶图(SDS-PAGE zymograph)和Western blotting的方法检测20例AMI患者发病后第1、3、7天血清中MMP-2的水平。结果:与对照组相比,AMI患者发病后的第1天血清MMP-2的表达2倍增高(P<0.001),在发病后第3、7天血清中仍保持高水平MMP-2的表达,但与发病第1天相比差异无显著性意义(P>0.05)。结论:血清MMP-2在急性心肌梗死患者中明显增高,进一步证实了不稳定的斑块破裂而导致AMI与MMP-2的内在联系。
|
关 键 词: | 基质金属蛋白酶-2 急性心肌梗死 不稳定斑块 |
Serum levels of matrix metalloproteases-2 are elevated in acute myocardial infarction |
| |
Abstract: | Objective This study was to investigate the association between serum levles of matrix metalloproteases 2(MMP 2)and unstable plaques in patients with acute myocardial infarction (AMI).Methods Using SDS-PAGE enzymograph and Western blotting,serum MMP 2 were measured in 20 patients with acute myocardial infarction after 1,3 and 7 days.Results Serum MMP 2 in patients with AMI on day 1 was two times greater than that in control subject( P <0 001);day 3 and day 7 they still showed high MMP 2 levels but P >0 05.Conclusion Serum MMP 2 levels were high in patientswith AMI.This finding suggests association between MMP 2 and unstable plaques in AMI. |
| |
Keywords: | Acute rnyocardial infarction Matrix metalloproteases 2 Unstable plaque |
本文献已被 CNKI 维普 万方数据 等数据库收录! |