Cognitive and behavioral outcomes in benign childhood epilepsy with centrotemporal spikes |
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| Affiliation: | 1. Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China;2. Department of Radiology, The First Central Hospital of Tianjin, Tianjin, China;3. Tianjin Normal University, Tianjin, China;1. National Centre for Epilepsy, Division for Surgery and Clinical Neuroscience, Oslo University Hospital, Norway;2. Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway;3. Department of Neurology, Akershus University Hospital, Lørenskog, Norway;4. Division of Mental Health, Akershus University Hospital, Lørenskog, Norway;5. The National Institute of Health, Department of Mental Health, Norway;6. Department of Paediatrics, Oslo University Hospital, Norway;7. Department of Neurology, Division for Surgery and Clinical Neuroscience, Oslo University Hospital, Norway;8. Faculty of Medicine, University of Oslo, Norway;9. Department of Psychology, University of Oslo, Norway;1. Department of Neurology, University of Miami, Miller School of Medicine, 1120 NW 14th Street, Room #1324, Miami, FL 33136, USA;2. New York University Langone Medical Center, New York, NY 10016, USA;3. The Nathan Kline Institute, Orangeburg, NY, USA;4. Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY, USA;5. Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada;6. Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Road, Toronto, ON M4G 1R8, Canada;7. NS — Institute de Neurosciences des Systemes, UMR INSERM 1106, Aix-Marseille Université, Equipe Physionet, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France;8. Department of Pediatrics, Dalhousie University Halifax, Nova Scotia, Canada;9. Division of Neurology, Department of Medicine, Halifax Infirmary, Halifax B3H4R2, Nova Scotia, Canada;10. Departments of Psychology and Brain & Cognitive Sciences, Zlotowski Centre for Neuroscience, Ben-Gurion University of the Negev, Be''er Sheva, Israel;11. Centre for Mental Health, University of Toronto, University Health Network, Canada;12. Departments of Physiology and Cell Biology, Brain & Cognitive Sciences, Zlotowski Centre for Neuroscience, Ben-Gurion University of the Negev, Be''er Sheva, Israel;13. Departments of Medical Neuroscience and Pediatrics, Faculty of Medicine, Dalhousie University Halifax, NS, Canada;14. Brain Repair Center, Life Science Research Institute, Dalhousie University, Room 229, PO Box 15000, Halifax, Nova Scotia B3H4R2, Canada;1. Department of Paediatrics, University of Perugia, Italy;2. Department of Paediatrics, University of Chieti, Italy;3. Department of Child Neuropsychiatry, University of Salerno, Italy |
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| Abstract: | We review the evidence that BECTS may be associated with cognitive dysfunction and behavioral problems, the extent to which these problems may be associated with patterns of EEG abnormalities in BECTS, and the impact of antiepileptic medication on cognition and behavior in BECTS.A growing literature examining cognitive and behavioral outcomes suggests that children with BECTS perform below the level of their peers. Consistent with this, neuroimaging studies reveal that BECTS has an impact on structural and functional brain development, but the potential influence of frequency and lateralization of centrotemporal spikes (CTS) on cognition and behavior is not well understood. Treatment with AEDs is an option in BECTS, but existing studies have not clearly shown a clear relationship between elimination of CTS and improved cognitive or behavioral outcomes. |
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