Yellow fever |
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Affiliation: | 1. Adolfo Lutz Institute, São Paulo, SP, Brazil;2. Department of Zoology, University of Oxford, United Kingdom;3. Institute of Tropical Medicine, University of São Paulo, SP, Brazil;4. Superintendence for Control of Endemic Diseases, São Paulo, SP, Brazil;5. Centro de Vigilância Epidemiológica "Prof. Alexandre Vranjac", São Paulo, SP, Brazil;6. Superintendence for Control of Endemic Diseases, Taubaté, SP, Brazil |
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Abstract: | Yellow fever, a mosquito-borne flavivirus disease occurs in tropical areas of South America and Africa. It is a disease of major historical importance, but remains a threat to travelers to and residents of endemic areas despite the availability of an effective vaccine for nearly 70 years. An important aspect is the receptivity of many non-endemic areas to introduction and spread of yellow fever. This paper reviews the clinical aspects, pathogenesis, and epidemiology of yellow fever, with an emphasis on recent changes in the distribution and incidence of the disease. Recent knowledge about yellow fever 17D vaccine mechanism of action and safety are discussed. |
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Keywords: | Yellow fever Pathogenesis Epidemiology |
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