CMV induces HERV-K and HERV-W expression in kidney transplant recipients |
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| Affiliation: | 1. Department of Biomedicine, Aarhus University, Bartholin Building, Wilhelm Meyers Allé 4, DK-8000 Aarhus C, Denmark;2. Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, DK-8000 Aarhus C, Denmark;1. Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy;2. Centro Sclerosi Multipla, Dipartimento di Sanità Pubblica Medicina Clinica e Molecolare, Università di Cagliari, Via Is Guadazzonis 2, 09126 Cagliari, Italy;1. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA;1. Immunology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid. Spain;2. Multiple Sclerosis Unit, Neurology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid. Spain |
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| Abstract: | BackgroundHuman endogenous retrovirus (HERVs) constitute approximately 8% of the human genome. Induction of HERV transcription is possible under certain circumstances, and may have a possible role in some pathological conditions.ObjectivesThe aim of this study was to evaluate HERV-K and –W pol gene expression in kidney transplant recipients and to investigate the possible relationship between HERVs gene expression and CMV infection in these patients.Study designThirty-three samples of kidney transplant patients and twenty healthy blood donors were used to analyze, HERV-K and –W pol gene RNA expression by relative quantitative relative Real-Time PCR.ResultWe demonstrated that HERVs pol gene expression levels were higher in kidney transplant recipients than in healthy subjects. Moreover, HERV-K and –W pol gene expression was significantly higher in the group of kidney transplant recipients with high CMV viral load than in the groups with no or moderate CMV viral load.ConclusionOur data suggest that CMV may facilitate in vivo HERV activation. |
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| Keywords: | Cytomegalovirus Retrovirus HERV Transplant recipient Biomarker Cancer |
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