Benzo(a)pyrene-induced cytochrome p4501A expression of four freshwater fishes (Oryzias latipes,Danio rerio,Cyprinus carpio,and Zacco platypus) |
| |
| Affiliation: | 1. Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Sciences, China Agricultural University, Beijing, 100193, China;2. State Key Laboratory for Biology of Plant Disease and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China;1. Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 440-746, South Korea;2. Department of Medical Elementology and Toxicology, Hamdard University, New Delhi 110062, India |
| |
| Abstract: | Oryzias latipes, Danio rerio, Cyprinus carpio, and Zacco platypus are useful indicator species for CYP1A biomarker studies; however, comparative studies have not been performed. To compare susceptibility, dose- and time-dependent CYP1A induction at the mRNA and protein levels in response to benzo(a)pyrene (BaP) exposure was analyzed. At the mRNA level, a statistically significant difference was found among the four species; however, such was not observed at the protein level. C. carpio showed the highest CYP1A induction level and the steepest slope in the dose–response curve. To assess susceptibility, the difference in CYP1A mRNA induction among species must be considered, and C. carpio was the most sensitive species of the four evaluated in terms of CYP1A expression. |
| |
| Keywords: | Cytochrome P450 1A Biomarker |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
