| HPLC-MS-MS测定盐酸西替利嗪血药浓度及药动学研究 |
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| 引用本文： | 廖日房,叶琳,温预关. HPLC-MS-MS测定盐酸西替利嗪血药浓度及药动学研究[J]. 中国医院用药评价与分析, 2008, 8(10): 756-759 |
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| 作者姓名： | 廖日房 叶琳 温预关 |
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| 作者单位： | 1. 中山大学附属第二医院临床药学部,广州市,510120
2. 广州市脑科医院临床药理研究基地,广州市,510370 |
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| 基金项目： | 广东省医院药学研究基金，广州市医药卫生科技计划 |
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| 摘 要： | 目的：研究国产盐酸西替利嗪咀嚼片的人体药动学。方法：选择20名男性健康志愿者，采用HPLC—MS—MS测定单剂量（20mg）口服国产盐酸西替利嗪咀嚼片后，西替利嗪在人体内的浓度。结果：盐酸西替利嗪的体内动态过程呈一级吸收的二房室开放模型，Cmax、Tmax、T1/2、AUC11-36、AUC11-30分别为209．97±28．26μg·L^-1，1．6±0．3h，9．18±3．44h，1545．5±441．5μg·h·L^-1，1633．4±479．0μg·h·L^-1，结论：国产盐酸西替利嗪片与进口片具有生物等效性。
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| 关 键 词： | 盐酸西替利嗪 药动学 高效液相色谱法 生物利用度 |
Determination of Serum Concentration of Cetirizine Hydrochloride Tablets by HPLC-MS-MS and Its Pharmacokinetics |
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| LIAO Ri-fang,YE Lin,WEN Yu-guan. Determination of Serum Concentration of Cetirizine Hydrochloride Tablets by HPLC-MS-MS and Its Pharmacokinetics[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2008, 8(10): 756-759 |
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| Authors: | LIAO Ri-fang YE Lin WEN Yu-guan |
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| Affiliation: | LIAO Ri-fang , YE Lin, WEN Yu-guan(1. Dept. of Clinical Pharmacy, The Second Affiliated Hospital of Sun YatSen University, Guangzhou 510120, China; 2.Clinical Pharmacological Centre of Guangzhou Brain Hospital, Guangzhou 510370, China) |
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| Abstract: | OBJECTIVE： To study the pharmacokinetics of Cetirizine Hydrochtoride Tablets in healthy volunteers. METHODS ： HPLC - MS - MS was applied for the determination of serum concentration of Cetirizine in 20 healthy volunteers after a single oral dose of 20 mg domestic Cetirizine Hydroehloride Tablets. RESULTS： The dynamic process of Cetirizine conformed to a two- compartment open model （first order absorption）. The main pharmacokinetie parameters of domestic Cetirizine Hydrochloride were as follows： C T T1/2 , AUC0-36, AUC0- 330 and Cmax were 209.97±28.26μg·L^-1,1.6±0.3h,9.18±3.44h,1545.5±441.5μg·h·L^-1,1633.4±479.0μg·h·L^-1, respectively. CONCLUSION ： The domestic Cetirizine Hydrochloride and imported Cetirizine Hydrochloride Tablets are bioequivalent. |
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| Keywords: | Cetirizine hydrochloride Pharmaeokineties HPLC Bioavailability |
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