| Abstract: | The effects of bradykinin, morphine, and naloxone applied by microiontophoresis on sensomotor cortical neurons were studied in waking rabbits. Bradykinin increased the discharge frequency of most neurons. Morphine inhibited unit activity. Against the background of morphine, bradykinin had no activating action. Naloxone abolished the depriming effect of morphine and restored the response of the neurons to bradykinin. It is concluded that bradykinin interacts with opiate receptors in the brain.Laboratory of Molecular Neurophysiology and Biochemistry, P. K. Anokhin Institute of Normal Physiology, Academy of Medical Sciences of the USSR, Moscow. Laboratory of Pharmacology of the Nervous System, Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Zakusov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 88, No. 12, pp. 683–685, December, 1979. |
