| 非小细胞肺癌微卫星不稳定性与临床分期的关系 |
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| 引用本文： | 姜斌 王卫星. 非小细胞肺癌微卫星不稳定性与临床分期的关系[J]. 第二军医大学学报, 2000, 21(11): 1080-1081 |
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| 作者姓名： | 姜斌 王卫星 |
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| 作者单位： | [1]第二军医大学长海医院肿瘤科,上海 [2]血液科,上海 |
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| 摘 要： | 目的：检测微卫星不稳定性（ＭＳＩ）与非小细胞肺癌（ＮＳＣＬＣ）临床分期的关系。方法：采用聚合酶链反应扩增，变性聚丙烯酰胺凝胶电泳等技术，分别选用定位于Ｘ及２１号染色体的ＡＲ和ＵＴ７６２微卫星标记位点，对３０例ＮＳＣＬＣ标本作ＭＳＩ测定。所有ＮＳＣＬＣ分期均采用国际抗癌联盟１９８９年分期标准。结果：ＡＲ位点ＭＳＩ阳性７例（２３％），ＵＴ７６２位点阳性６例（２０％）。总阳性病例１３例（４３％）。早期（Ⅰ期、Ⅱ期１１例）９例阳性（８２％），晚期（Ⅲａ期、Ⅲｂ期１９例）４例阳性（２１％）两者阳性率有显著性差异（Ｐ〈０．０１）。结论：ＭＳＩ为早期ＮＳＣＬＣ的重要标志之一，对其预后判断有一定指导意义。
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| 关 键 词： | 非小细胞肺癌 微卫星不稳定性 临床分期 |
| 文章编号： | 0258-879X(2000)011-1080-02 |
| 修稿时间： | 2000-05-14 |
Microsatellite instability in non-small cell lung cancer and its relationship to clinical staging |
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| JIANG Bin ,WANG Ya Jie ,WANG Wei Xing. Microsatellite instability in non-small cell lung cancer and its relationship to clinical staging[J]. Former Academic Journal of Second Military Medical University, 2000, 21(11): 1080-1081 |
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| Authors: | JIANG Bin WANG Ya Jie WANG Wei Xing |
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| Affiliation: | JIANG Bin 1,WANG Ya Jie 1,WANG Wei Xing 2 |
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| Abstract: | Objective:To study the relationship between microsatelliteinstability(MSI) and clinical staging in non-small cell lung cancer (NSCLC).Methods:Two microsatellite repeat sequences AR (chromosome X),UT762 (chromosome 21) were examined in normal and tumor pairs from 30 NSCLC patients by PCR and denatured polyacrylamide gel electrophoresis.Resuits:MSI positivity for AR and UT loci was 7/30 and 6/30 respectively,totaling 13/30.According to ulcc,9/11(82％) belonged in stage Ⅰ and Ⅱ (early stag3),and 4/19 (21%) in stage Ⅲa and Ⅲb(late stage).Conclusion:MSI is an important marker in early NSCLC and analysis of MSI may have some significance in prognosis of NSCLC. |
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| Keywords: | lung cancer non small microsatellite instability clinical staging |
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