| 乙型肝炎患者血清前S1抗原与e抗原及HBV-DNA载量相关性的探讨 |
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| 引用本文： | 盛仅翠.乙型肝炎患者血清前S1抗原与e抗原及HBV-DNA载量相关性的探讨[J].安徽医药,2009,13(6):630-631. |
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| 作者姓名： | 盛仅翠 |
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| 作者单位： | 安庆市立医院感染性疾病科,安徽,安庆,246003 |
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| 摘 要： | 目的探讨前S1抗原（PreS1）与e抗原（HBeAg）及HBV-DNA载量相关性,评价PreS1的临床检测意义。方法对160例未经抗病毒治疗的慢性乙型肝炎患者采用实时荧光定量PCR法测定HBV-DNA,ELISA法检测PreS1和HBeAg。结果PreS1在乙型肝炎e抗原（HBeAg）阳性组中检出率为84.8%,高于其在HBeAg阴性组中的检出率35.1%（P〈0.01）;HBV DNA阳性组中PreS1阳性率为76.6%,显著高于HBV DNA阴性组的53.4%（P〈0.05）。随着HBV-DVA载量的升高,PreS1和HBeAg的阳性率也随之升高,在HBV-DNA低载量时,PreS1的阳性率明显高于HBeAg。结论HBV PreS1抗原与具有病毒复制活动性意义的指标（HBeAg和HBV DNA）有良好的相关性,PreS1抗原能够比HBeAg更灵敏地反映HBV复制。
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| 关 键 词： | 肝炎病毒 乙型 前S1抗原 e抗原 HBV DNA |
Relativity among PreS_1,HBeAg and the level of serum HBV-DNA |
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| SHENG Jin-cui.Relativity among PreS_1,HBeAg and the level of serum HBV-DNA[J].Anhui Medical and Pharmaceutical Journal,2009,13(6):630-631. |
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| Authors: | SHENG Jin-cui |
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| Institution: | SHENG Jin-cui(Department of Infectious Diseases,Anqing Municipal Hospital,Anqing Anhui 240023) |
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| Abstract: | Aim To study the relationship among PreS1,HBeAg and the level of serum HBV-DNA,and to evaluate the clinical significance of PreS1.Methods 160 patients with chronic hepatitis B were selected.Serum level of HBV-DNA was determined by real-time fluorescence quantity PCR.Serum PreS1 and HBeAg were determined by ELISA.Results The detectable rate of PreS1 antigen in positive HBeAg group(84.8%) was higher than that in negative HBeAg group(35.1%)(P<0.01).The detectable rate of PreS1 antigen in positive HBV DNA group... |
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| Keywords: | HBV DNA |
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